Recipes and Stuff

Recipes, Food, Health, Lifestyle, and News

Menu
  • Industry News
  • Cakes
  • Soups
  • Vegan lifestyle
  • Indian recipes
  • Desserts
  • Blog
  • About
Menu

Evgen Pharma expands collaboration with Manchester Breast Centre

Posted on March 7, 2022March 7, 2022 by Kiran
Evgen Pharma expands collaboration with Manchester Breast Centre

LONDON: Evgen Pharma plc (AIM: EVG), a clinical stage drug development company, announced an expansion of its collaboration with the Manchester Breast Centre at the University of Manchester’s School of Medical Sciences, in a continued drive to establish the optimum clinical positioning for lead asset SFX-01 in metastatic breast cancer (“mBC”).

Since the STEM open-label Phase II trial of SFX-01 in mBC trial concluded, CDK4/6 inhibitors have become standard of care as the first line mBC treatment for the large group of patients who are estrogen receptor positive (ER+ve), human epidermal growth factor receptor 2 negative (“HER-2 negative”).

These drugs provide an extended period of progression-free survival, but invariably patients’ tumours become resistant to them. Options for such patients are limited, especially since drugs used in this setting are poorly tolerated.

Accordingly, Evgen is expanding its work with Professor Rob Clarke at the Manchester Breast Centre with in vitro preclinical work to assess the impact of SFX-01 in CDK4/6 resistance models.

An increasing body of in vitro data from these models shows that SFX-01 may suppress tumour growth and metastasis in patients who have become resistant to CDK4/6 inhibitors. In particular, SFX-01 reduces the viability and mammosphere colony formation of palbociclib-resistant tumour cell lines in vitro.

In addition, the extended collaboration will include in vivo models to provide the optimum support for clinical trial design and/or licensing in patients with HER-2 negative, ER+ve breast cancer, where CDK4/6 inhibitors such as palbociclib are showing weakening effectiveness. Evgen anticipates data from both in vitro and in vivo work later in the year.

Palbociclib, marketed by Pfizer, is the leading CDK4/6 inhibitor; in 2019 it had sales of circa $5bn.

Dr Huw Jones, Evgen CEO, commented: “We are delighted to expand this collaboration with Rob and Dr Bruno Simões and the team, and we remain passionate about optimising the use of SFX-01 to improve patient outcomes. Breast cancer remains our top priority alongside brain cancer, and we hope ultimately to provide an effective treatment for these patients as the current options for treatment become more limited.”

Prof Rob Clarke, Professor of Breast Biology at the University of Manchester, added: “We look forward to working closely with the Evgen Pharma team to advance our work on SFX-01 in breast cancer, and to demonstrate its effectiveness in patients who are resistant to the current standard of care treatments.”

 www.evgen.com

1 thought on “Evgen Pharma expands collaboration with Manchester Breast Centre”

  1. 먹튀검증업체 says:
    March 8, 2022 at 4:53 am

    Hello there, I found your website by the use
    of Google even as looking for a related topic, your site came up, it appears good.
    I have bookmarked it in my google bookmarks.
    Hi there, just turned into alert to your weblog thru Google, and located
    that it’s really informative. I’m gonna watch out for brussels.
    I’ll be grateful in case you continue this in future.

    A lot of folks will probably be benefited from your writing.
    Cheers!

    Reply

Leave a Reply Cancel reply

Your email address will not be published. Required fields are marked *

Recent Posts

  • Target Healthcare sells four care homes in Northern Ireland
  • AEW UK REIT plc announces acquisition of high yielding retail warehousing unit in Preston
  • Tips to eating right during the summers
  • How to become a good chef?
  • Dubai’s most popular tourist destinations: The Atlantis Hotel Palm Jumeirah
  • Blog
  • Cakes
  • Desserts
  • Indian recipes
  • Industry News
  • Recipes
  • Soups
  • Trending Beverages
  • Uncategorized
  • Vegan lifestyle

Archives

  • March 2023
  • February 2023
  • January 2023
  • December 2022
  • November 2022
  • October 2022
  • September 2022
  • August 2022
  • July 2022
  • June 2022
  • May 2022
  • April 2022
  • March 2022
  • February 2022
  • January 2022
©2023 Recipes and Stuff | Theme by SuperbThemes